Wilson entered the comics industry in the early 1970s at Marvel Comics where he produced both cover illustrations and interior artwork. He was the regular artist on Marvel Two-in-One from 1975–1978 and again from 1980–1983; while additionally working on titles such as Black Goliath, Power Man, The Hulk! and Captain Britain.
In the 1980s, after the cancellation of Marvel Two-in-One, Wilson teamed with writer John Byrne on The Thing (1983–1986). In 1983 he plotted and drew "Super Boxers" (Marvel Graphic Novel #8). He drew the entire run of Marvel's Masters of the Universe (1986–1988) and the Wolfpack limited series (1988–1989). Wilson's work also appeared in The Avengers, Captain America, Deadly Hands of Kung Fu, Iron Man, and What If.
In 1990, Wilson illustrated an issue of Urth 4 for Continuity Comics, and then returned to Marvel to draw WCW World Championship Wrestling in 1992–1993. His work appeared regularly in Marvel Comics Presents in 1992–1994. Wilson contributed to the crafting of DC Comics Milestone Media imprint providing character design work and pencilled an issue of Icon as well as the DC universe mini-series Arion the Immortal. In 2008, he provided a cover for the second issue of the pro wrestling-themed mini-series Headlocked published by Visionary Comics. As of 2012, Wilson was preparing a new creator-owned project Battle Rappers.